Haplotype Analysis in Multiple Crosses to Identify a QTL Gene
نویسندگان
چکیده
منابع مشابه
Haplotype analysis in multiple crosses to identify a QTL gene.
Identifying quantitative trait locus (QTL) genes is a challenging task. Herein, we report using a two-step process to identify Apoa2 as the gene underlying Hdlq5, a QTL for plasma high-density lipoprotein cholesterol (HDL) levels on mouse chromosome 1. First, we performed a sequence analysis of the Apoa2 coding region in 46 genetically diverse mouse strains and found five different APOA2 protei...
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MAPfastR is an R package for mapping quantitative trait loci (QTL) in outbred line crosses. It contains all the functions required to perform a QTL analysis in outbred lines. Some of the functions implement different algorithms that can be used interchangeably and it is up to the user to decide which will be applied. This gives the user a certain degree of flexibility when constructing the anal...
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Background: Recent studies demonstrated the multifactorial and chronic nature of male infertility, including mutations of some known spermatogenesis-related genes. The H2B family, member W (H2B.W) gene is one of the testis specific histone variant genes that encodes a sperm telomere-binding protein, required for reorganization and integration of sperm chromosomes. The objective of the present s...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2004
ISSN: 1088-9051
DOI: 10.1101/gr.2668204